eSports betting has become an increasingly popular form of online gambling, as competitive gaming continues to grow in popularity. While eSports betting has much potential, it also comes with some unique challenges. 2021 has been a particularly difficult year for the eSports betting market, as the pandemic has changed the way gambling activities can be conducted and promoted. From changing business models and increased competition to fragmented markets and a lack of regulation, the 2021 eSports betting market has faced unprecedented challenges over the course of the year. Those wishing to venture into the world of eSports gambling must be aware of the difficulties they could face and be prepared to make the necessary changes to their business approach to overcome them.